explore the beautiful garden bathroom style at villa kouru batu belong bali, featuring an outdoor bathtub surrounded by lush plants and rocks. designed by bali landscape company.
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ann nordgren | karolinska institutet
ann nordgren presently serve as adjunct professor of clinical genetics at karolinska institutet and senior consultant and project manager at the karolinska center for rare diseases (kcrd) at clinical genetics, karolinska university hospital. currently, ann nordgren is a swedish board certified specialist in clinical genetics since 2002. her clinical work is mainly focused on genetic counceling, syndrome diagnostics and childhood cancer diagnostics using detailed phenotyping as well as molecular, cytogenetic and massive parallell sequencing techniques. in 2012 ann nordgren started a clinical and research multidisciplinary expert team for syndrome diagnostics. and this team is now going to be part of the international undiagnosed diseases program (udp). she is also leading a national collaborative work to create a national quality registry for rare diseases. ann nordgren has a 6-year research position financed by the swedish childhood cancer foundation.her position as researcher and project leader of kcrd has led to fruitful collaborations with patients, patient organisations, politicians, european commission, the national board of health and welfare, healthcare professionals, orphan drug industry. she is a board member of Ågrenska and a deputie in the nordic network for rare diseases, commissioned by the nordic council as well as board member of Ågrenska ab, sällsyntafonden, the swedish pediatric genetics association, and the international conference of rare diseases and orphan drugs (icord). she is also a member of the irdirc diagnostics scientific committee and member of the undiagnosed diseases network (udni), member of the research grant prioritization committee at the swedish cancer society and the swedish coordinator of a european reference network (ern) for congenital malformations and intellectual disability as well as national coordinator for the nordic childhood cancer etiology group.
15. a ruined villa of tangled gardens
15. a ruined villa of tangled gardens was published in the tale of genji on page 81.
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15. a ruined villa of tangled gardens
15. a ruined villa of tangled gardens was published in the tale of genji on page 81.
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an early prediction model for gestational diabetes mellitus based on genetic variants and clinical characteristics in china - diabetology & metabolic syndrome
objectives to evaluate the influence of genetic variants and clinical characteristics on the risk of gestational diabetes mellitus (gdm) and to construct and verify a prediction model of gdm in early pregnancy. methods four hundred seventy five women with gdm and 487 women without, as a control, were included to construct the prediction model of gdm in early pregnancy. both groups had complete genotyping results and clinical data. they were randomly divided into a trial cohort (70%) and a test cohort (30%). then, the model validation cohort, including 985 pregnant women, was used for the external validation of the gdm early pregnancy prediction model. results we found maternal age, gravidity, parity, bmi and family history of diabetes were significantly associated with gdm (or > 1; p < 0.001), and assisted reproduction was a critical risk factor for gdm (or = 1.553, p = 0.055). mtnr1b rs10830963, c2cd4a/b rs1436953 and rs7172432, cmip rs16955379 were significantly correlated with the incidence of gdm (aor > 1, p < 0.05). therefore, these four genetic susceptible single nucleotide polymorphisms (snps) and six clinical characteristics were included in the construction of the gdm early pregnancy prediction model. in the trial cohort, a predictive model of gdm in early pregnancy was constructed, in which genetic risk score was independently associated with gdm (aor = 2.061, p < 0.001) and was the most effective predictor with the exception of family history of diabetes. the roc-auc of the prediction model was 0.727 (95% ci 0.690–0.765), and the sensitivity and specificity were 69.9% and 64.0%, respectively. the predictive power was also verified in the test cohort and the validation cohort. conclusions based on the genetic variants and clinical characteristics, this study developed and verified the early pregnancy prediction model of gdm. this model can help screen out the population at high-risk for gdm in early pregnancy, and lifestyle interventions can be performed for them in a timely manner in early pregnancy.
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13. the lady at akashi
13. the lady at akashi was published in the tale of genji on page 73.
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13. the lady at akashi
13. the lady at akashi was published in the tale of genji on page 73.
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15. a ruined villa of tangled gardens
15. a ruined villa of tangled gardens was published in the tale of genji on page 81.
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